Activated partial thromboplastin time. This test also gives information about factors in blood clotting. And it's used to measure the effects of heparin. Many things may affect your lab test results. These include the method each lab uses to do the test. Even if your test results are different from the normal value, you may not have a problem.
To learn what the results mean for you, talk with your healthcare provider. A longer thrombin time can mean low fibrinogen, high fibrinogen, or fibrinogen that's not working normally. It can also be because of medicines that affect blood clotting, such as heparin or argatroban.
A longer thrombin time can be caused by proteins in the blood from multiple myeloma or amyloidosis. Or it could be caused by antibodies to cow thrombin, which is used as part of the testing. The test is done with a blood sample. A needle is used to draw blood from a vein in your arm or hand. The sample is placed in a tube containing a chemical that keeps it from clotting. Having a blood test with a needle carries some risks.
These include bleeding, infection, bruising, and feeling lightheaded. When the needle pricks your arm or hand, you may feel a slight sting or pain. Afterward, the site may be sore. Some medicines that alter blood clotting will affect your test results, such as heparin and warfarin. Tell your healthcare provider if you're taking any medicines, especially those that affect your blood's ability to clot. Be sure your healthcare provider knows about all medicines, herbs, vitamins, and supplements you are taking.
Search Encyclopedia. Thrombin Time Does this test have other names? The test may be used to help diagnose problems such as: Inherited conditions that lead to low fibrinogen or fibrinogen disorders Liver diseases such as cirrhosis, hepatitis, and liver cancer Cancers such as kidney cancer renal carcinoma or multiple myeloma Certain other health conditions, including lupus and ulcerative colitis Antibodies against fibrinogen your body may be making, if you had surgery that uses fibrin glue from cow sources Disseminated intravascular coagulation, a condition in which your body uses more fibrinogen Some medicines can also lead to a longer thrombin time.
You may need this test if your blood does not seem to be clotting normally. Symptoms can include: Excessive bleeding or bruising Pregnancy problems, such as repeated miscarriages early in pregnancy, and abnormal bleeding after delivery What other tests might I have along with this test?
These may include: Reptilase time. The binding of a cation introduces changes in the distribution of these states. Through comparisons with potassium-binding, the binding of sodium ions appears to shift the population toward conformational states that might be catalytically favorable.
Xiao, R. Melvin and F. Salsbury, Phys. To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page. If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given. If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given.
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Please enable JavaScript to access the full features of the site or access our non-JavaScript page. Issue 36, From the journal: Physical Chemistry Chemical Physics. Jiajie Xiao , ab Ryan L. Melvin ac and Freddie R.
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