PPAR-alpha is a protein that helps make peroxisomes, burn fat, and boosts weight loss [ 8 , 9 ]. DHEA has a much stronger effect, but both may boost the growth of estrogen-sensitive cells [ 12 , 13 ]. No valid clinical evidence supports the use of 7-keto DHEA for any of the conditions in this section. Below is a summary of up-to-date animal studies, cell-based research, or low-quality clinical trials which should spark further investigation.
In a study of 40 subjects, 7-keto was used both alone and in combination with other supplements green tea extract, vitamin C , chromium , and vitamin D 3. Both options increased the metabolic rate, helping to burn more calories. The overweight patients were also on a calorie-restricted diet [ 17 ]. In mice, 7-Keto stimulated weight loss in fully grown mice; it reduced appetite, which is crucial for weight loss [ 18 ].
More research is needed to evaluate the effects of 7-keto DHEA on fat metabolism and weight control. Cortisol levels will increase after a short period of stress , but may rapidly fall if the stress is prolonged. In one study, 7-Keto 25 mg single doses gel was applied to the skin of 10 healthy men. After five days the cortisol levels decreased by 7. No clinical evidence supports the use of 7-keto DHEA for any of the conditions listed in this section.
Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.
In one study, scientists observed the potential of 7-Keto to improve memory in both young and old mice with memory impairment. The effect was much stronger in young mice, in which 7-Keto completely reversed memory loss [ 21 ].
In one study, chronic mild stress reduced thyroid hormones and immune response T cells in mice with induced depression. Scientists observed the potential of 7-keto DHEA to reduce depressive symptoms and restore thyroid hormones and immune cell levels to normal [ 22 ]. In one study, 7-Keto DHEA reduced the alcohol-seeking behavior and alcohol blood levels in mice [ 23 ].
In another rat study, it reduced alcohol intake. It had a stronger effect than DHEA at the same doses [ 24 ]. The biological functions, role in disease, and mechanism of action of 7-Keto DHEA are still under investigation. Studies done on rats and mice may not continue to hold true in humans [ 2 ]. Despite its relatively safe track record as a supplement, there are other considerations to keep in mind if you choose to try 7-Keto.
WADA is responsible for the World Anti-Doping Code, which provides a framework for anti-doping policies, rules and regulations within sports organizations. To date, more than sports organizations, including the International Olympic Committee IOC , have implemented this code While 7-Keto does not affect hormone levels in your body when taken as an oral supplement, it may influence them if applied to the skin as a gel.
Several studies have shown that when applied to the skin, 7-Keto can affect sex hormones, cholesterol and thyroid function in men. It remains unknown how 7-Keto gel affects women 16 , 17 , Studies suggest that it may be effective when used alongside a reduced-calorie diet and exercise. Despite these concerns, the evidence is still too limited to recommend 7-Keto for boosting your metabolism or losing weight. Your metabolism determines how many calories you burn each day. Here are 9 easy ways to boost your metabolism, backed by science.
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